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Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway.
- Source :
-
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2019 Jun 01; Vol. 24 (8), pp. 1477-1486. Date of Electronic Publication: 2019 Jun 01. - Publication Year :
- 2019
-
Abstract
- Diabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus, for which no effective treatment currently exists. We tested the hypothesis that Qi-dan-di-huang (QDDH) might have therapuetic effects in an experimental rat model of DN. The levels of I kappa KinaseAlpha and Beta, p-p65, p-IκB alpha, TGF-β1 and Alpha-SMA were significantly increased in kidneys in DN. QDDH decoction only partially reversed the increased Ikappa KinaseAlpha/Beta, p-p65, p-IKappaB alpha, TGF-Beta1 and alpha-SMA in the kidneys in DN. However, treatment of diabetic rats with QDDH decoction significantly inhibited the production and release of inflammatory cytokines IL-6, IL-1 beta and TNF-alpha into the serum. QDDH decoction also significantly improved the physiologic and biochemical indicators of DN, reduced glycogen and protein deposition in DN and prevented renal fibrosis. Together, the data show that QDDH decoction exerts a protective effect on kidneys in diabetic rats and reverses the inflammatory milieu of the serum in DN.
- Subjects :
- Animals
Cytokines blood
Diabetic Nephropathies complications
Diabetic Nephropathies metabolism
Fibrosis
Glycogen metabolism
Humans
Inflammation Mediators blood
Kidney drug effects
Kidney metabolism
Kidney pathology
Male
Rats, Sprague-Dawley
Diabetes Mellitus, Experimental complications
Diabetic Nephropathies prevention & control
Drugs, Chinese Herbal pharmacology
NF-kappa B metabolism
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2768-6698
- Volume :
- 24
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Frontiers in bioscience (Landmark edition)
- Publication Type :
- Academic Journal
- Accession number :
- 31136992
- Full Text :
- https://doi.org/10.2741/4792