A novel fluorescent chemosensor for detection of Zn(II) ions based on dansyl-appended dipeptide in two different living cells.

Authors :: Wang P
Wu J
An Y
Liao Y
Source :: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2019 Sep 05; Vol. 220, pp. 117140. Date of Electronic Publication: 2019 May 20.
Publication Year :: 2019
Abstract: This paper describes a new fluorescent chemosensor (DSH) based on dipeptide conjugated with dansyl group, which was synthesized by solid phase peptide synthesis (SPPS) technology. DSH exhibited a highly selective and sensitive toward Zn <superscript>2+</superscript> ions by "turn-on" response based on generation of monomer-excimer mechanism in aqueous solutions, and the detection limit was calculated at 11.2 nM. In addition, the reversible of DSH-Zn with Na <subscript>2</subscript> EDTA establishes the reuse of DSH, and the circulation effect was very good. Moreover, DSH had good water solubility, and was successfully applied to bioimage intracellular Zn <superscript>2+</superscript> ions and Na <subscript>2</subscript> EDTA in two different living cells with exciting cellular permeability and low cytotoxicity, which indicated that DSH had great potential in the application of biological imaging.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Language :: English
ISSN :: 1873-3557
Volume :: 220
Database :: MEDLINE
Journal :: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Publication Type :: Academic Journal
Accession number :: 31136861
Full Text :: https://doi.org/10.1016/j.saa.2019.117140

Full Text Access

Tools