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Conjunctival Melanoma in Asian Indians: A Study of 42 Patients.
- Source :
-
Seminars in ophthalmology [Semin Ophthalmol] 2019; Vol. 34 (3), pp. 182-187. Date of Electronic Publication: 2019 May 28. - Publication Year :
- 2019
-
Abstract
- Purpose: To describe the clinical features, treatment, and outcomes of conjunctival melanoma in Asian Indians. Methods: Retrospective study of 42 patients. Results: The mean age at presentation of conjunctival melanoma was 43 years (median, 45 years; range, 9-78 years). There were 20 (48%) males and 22 (52%) females. Nineteen patients (45%) had a known history of a preexisting pigmented conjunctival lesion. Bulbar conjunctiva (n = 28; 67%) was the most common tumor epicenter, and medial ocular surface quadrant (n = 15; 36%) was more commonly involved. The mean tumor basal diameter was 12 mm (median, 10 mm; range, 4-30 mm), and the mean tumor thickness was 4 mm (median, 2 mm; range, 1-30 mm). Majority of the patients had a pigmented tumor (n = 33; 79%). The tumors arose de novo (n = 17, 41%) or were associated with conjunctival nevus (n = 9; 21%) or primary acquired melanosis (n = 16, 38%). Wide excisional biopsy, adjunctive cryotherapy, and amniotic membrane grafting were performed in 27 (71%) patients, 11 (29%) underwent orbital exenteration, and 4 were lost to follow-up prior to definitive treatment. Over a mean follow-up period of 24 months (median, 9 months; range, <1 to 136 months), four (11%) patients had tumor recurrence, seven (18%) had locoregional lymph node metastasis, and four (11%) developed systemic metastasis and died due to metastatic disease. Conclusion: Conjunctival melanoma predominantly occurs in middle-aged Asian Indians and is associated with a high rate of systemic metastasis and death.
- Subjects :
- Adolescent
Adult
Age Distribution
Aged
Amnion transplantation
Asian People
Child
Cryotherapy methods
Female
Humans
Incidence
India epidemiology
Male
Middle Aged
Neoplasm Metastasis pathology
Neoplasm Recurrence, Local epidemiology
Retrospective Studies
Sex Distribution
Young Adult
Conjunctival Neoplasms epidemiology
Conjunctival Neoplasms pathology
Conjunctival Neoplasms surgery
Conjunctival Neoplasms therapy
Melanoma epidemiology
Melanoma pathology
Melanoma surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5205
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Seminars in ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 31135259
- Full Text :
- https://doi.org/10.1080/08820538.2019.1620793