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Study on antidepressant-like effect of protoilludane sesquiterpenoid aromatic esters from Armillaria Mellea .
- Source :
-
Natural product research [Nat Prod Res] 2021 Mar; Vol. 35 (6), pp. 1042-1045. Date of Electronic Publication: 2019 May 28. - Publication Year :
- 2021
-
Abstract
- Armillaria mellea , also known as Hazel mushroom, is a delicious food material and traditional herbal medicine in East Asia. Protoilludane sesquiterpenoid aromatic esters from A. mellea (PSAM) are the main active components with antibacterial and anticancer activities. This study explored the antidepressant-like activities of PSAM and its possible mechanisms of action using the open field test (OFT), tail suspension test (TST) and forced swimming test (FST) in mice for the first time. The results revealed that PSAM (1 mg/kg, i.p.) exhibited markedly antidepressant-like activity, which could be reversed by pretreatment with haloperidol (a non-selective D <subscript>2</subscript> receptor antagonist), bicuculline (a competitive GABA antagonist), NMDA (an agonist at the glutamate site). Meanwhile, PSAM also effectively increased the hippocampus dopamine (DA) and γ -aminobutyric acid (GABA) and decreased the hippocampus glutamate (Glu) levels of mice, indicating that the antidepressant-like effect of PSAM might be mediated by the DAergic, GABAergic and Gluergic systems.
- Subjects :
- Animals
Antidepressive Agents pharmacology
Behavior, Animal drug effects
Depression drug therapy
Depression physiopathology
Dopamine metabolism
Fluoxetine pharmacology
Fluoxetine therapeutic use
Glutamic Acid metabolism
Hindlimb Suspension
Male
Mice
Motor Activity drug effects
Open Field Test
Polycyclic Sesquiterpenes pharmacology
Reboxetine pharmacology
Reboxetine therapeutic use
Swimming
gamma-Aminobutyric Acid metabolism
Antidepressive Agents therapeutic use
Armillaria chemistry
Esters therapeutic use
Polycyclic Sesquiterpenes therapeutic use
Sesquiterpenes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 31135223
- Full Text :
- https://doi.org/10.1080/14786419.2019.1614577