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Diterpenoid and triterpenoid glycosides from Clinopodium chinense .
- Source :
-
Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 25-33. Date of Electronic Publication: 2019 May 28. - Publication Year :
- 2021
-
Abstract
- Two new compounds, including a diterpenoid glycoside ( 1 ) and a triterpenoid glycoside ( 6 ), along with six known compounds were isolated from Clinopodium chinense . The structures of the new compounds were determined on basis of extensive spectral analysis and chemical method. Compounds 1 - 8 were evaluated for their insulin resistance effect and cytotoxic activity against the A549 and HepG2 cancer cell lines. None of the compounds were cytotoxic (IC <subscript>50</subscript> > 100 μM), while compounds 1 - 3 and 5 showed the activity of ameliorating insulin resistance in HepG2.
- Subjects :
- A549 Cells
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Diterpenes chemistry
Drug Evaluation, Preclinical
Glycosides chemistry
Glycosides pharmacology
Hep G2 Cells
Humans
Insulin Resistance
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts chemistry
Triterpenes chemistry
Diterpenes pharmacology
Lamiaceae chemistry
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 31135216
- Full Text :
- https://doi.org/10.1080/14786419.2019.1611811