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Diterpenoid and triterpenoid glycosides from Clinopodium chinense .

Authors :
Qu LX
Liu YQ
Wang Y
Wang H
Huang XL
Zhang ML
Mou YX
Xu TH
Zhu YD
Source :
Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 25-33. Date of Electronic Publication: 2019 May 28.
Publication Year :
2021

Abstract

Two new compounds, including a diterpenoid glycoside ( 1 ) and a triterpenoid glycoside ( 6 ), along with six known compounds were isolated from Clinopodium chinense . The structures of the new compounds were determined on basis of extensive spectral analysis and chemical method. Compounds 1 - 8 were evaluated for their insulin resistance effect and cytotoxic activity against the A549 and HepG2 cancer cell lines. None of the compounds were cytotoxic (IC <subscript>50</subscript>  > 100 μM), while compounds 1 - 3 and 5 showed the activity of ameliorating insulin resistance in HepG2.

Details

Language :
English
ISSN :
1478-6427
Volume :
35
Issue :
1
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
31135216
Full Text :
https://doi.org/10.1080/14786419.2019.1611811