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Vinflunine in the treatment of relapsed metastatic urothelial cancer: A systematic review and meta-analysis of real-world series.
- Source :
-
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2019 Aug; Vol. 140, pp. 80-87. Date of Electronic Publication: 2019 May 21. - Publication Year :
- 2019
-
Abstract
- Background: Vinflunine (VFL) is approved in Europe as second-line treatment of metastatic urothelial cancer after failure of platinum-containing therapy. We performed a systematic review and meta-analysis of real-world data (RWD) to assess utilization, efficacy and safety of VFL.<br />Methods: We performed a MEDLINE search for the period of 1/1/2000-31/8/2017. Full-length articles providing post-marketing RWD on VFL in patients failing previous chemotherapy were eligible. Interventional clinical trials were excluded.<br />Results: Ten studies with 797 patients were identified. According to pooled REs analysis, overall response rate was 19%, most frequent, all-grade toxicities were fatigue (41%), constipation (39%), nausea/vomiting (25%), and most prevalent Grade 3-4 toxicities were neutropenia (13%), anaemia (9%), fatigue (8%). Median OS was comparable to results reported in recent randomized studies.<br />Conclusion: Our findings confirm the efficacy and safety of VFL in an unselected population and support the use of VFL in the changing treatment paradigm of relapsed mUC.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Constipation chemically induced
Europe
Fatigue chemically induced
Female
Humans
Male
Middle Aged
Nausea chemically induced
Neoplasm Metastasis
Platinum Compounds therapeutic use
Recurrence
Treatment Outcome
Urologic Neoplasms pathology
Vinblastine adverse effects
Vinblastine therapeutic use
Vomiting chemically induced
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Urologic Neoplasms drug therapy
Vinblastine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0461
- Volume :
- 140
- Database :
- MEDLINE
- Journal :
- Critical reviews in oncology/hematology
- Publication Type :
- Academic Journal
- Accession number :
- 31133463
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2019.05.006