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Dr. Jekyll and Mr. Hide: How Enterococcus faecalis Subverts the Host Immune Response to Cause Infection.
- Source :
-
Journal of molecular biology [J Mol Biol] 2019 Jul 26; Vol. 431 (16), pp. 2932-2945. Date of Electronic Publication: 2019 May 25. - Publication Year :
- 2019
-
Abstract
- Enterococcus faecalis, a ubiquitous member of the healthy human gut microbiota, is also a common opportunistic pathogen and leading cause of nosocomial infections. This tenacious microbe is well adapted to infect and persist in multiple niches within the mammalian host and can rapidly tune its metabolism to respond to new environments, enabling infection in sites including the gastrointestinal tract, urinary tract, wounded epithelium, heart, and blood. In order to withstand and persist in the face of host immune responses, E. faecalis has an arsenal of strategies to suppress, evade, or inactivate innate and adaptive immune mechanisms. In this review, we present the variety of ways E. faecalis modulates the immune response, enabling this otherwise innocuous gut commensal to transition and persist as a pathogen.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adaptive Immunity
Blood immunology
Blood microbiology
Gastrointestinal Microbiome
Gastrointestinal Tract immunology
Gastrointestinal Tract microbiology
Heart microbiology
Humans
Immune System microbiology
Immunity, Innate
Urinary Tract immunology
Urinary Tract microbiology
Enterococcus faecalis pathogenicity
Immune System metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8638
- Volume :
- 431
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Journal of molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 31132360
- Full Text :
- https://doi.org/10.1016/j.jmb.2019.05.030