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Does cancer cell-expressed SLAMF7 impact on CD47-mediated phagocytosis?
- Source :
-
Molecular & cellular oncology [Mol Cell Oncol] 2019 Apr 16; Vol. 6 (3), pp. 1600349. Date of Electronic Publication: 2019 Apr 16 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Innate immune checkpoint CD47 has emerged as a prominent target for cancer immunotherapy and defining biomarkers predictive of response will be a crucial step towards clinical implementation. Hereto, we investigated the importance of a previously reported requisite for SLAM family member 7(SLAMF7) expression on cancer cell phagocytosis for effective CD47 antibody therapy.
Details
- Language :
- English
- ISSN :
- 2372-3556
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecular & cellular oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31131314
- Full Text :
- https://doi.org/10.1080/23723556.2019.1600349