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Profile of children with cerebral palsy spectrum disorder and a normal MRI study.
- Source :
-
Neurology [Neurology] 2019 Jul 02; Vol. 93 (1), pp. e88-e96. Date of Electronic Publication: 2019 May 24. - Publication Year :
- 2019
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Abstract
- Objective: This study looks at what profile can be expected in children with cerebral palsy spectrum disorder (CP) and a normal MRI.<br />Methods: The data were excerpted from the Canadian Cerebral Palsy Registry database. Only patients who had undergone MRI were included in the analysis. Neuroimaging classification was ascertained by university-based pediatric neuroradiologists and split into 2 categories: normal and abnormal MRIs. Six factors were then compared between those 2 groups: prematurity, perinatal adversity, presence of more than 1 comorbidity, CP subtype, bimanual dexterity (Manual Ability Classification System [MACS]), and gross motor function (Gross Motor Function Classification System [GMFCS]).<br />Results: Participants with no perinatal adversity were 5.518 times more likely to have a normal MRI ( p < 0.0001, 95% confidence interval [CI] 4.153-7.330). Furthermore, participants with dyskinetic, ataxic/hypotonic, and spastic diplegic forms of CP were 2.045 times more likely to have a normal MRI than those with hemiplegia, triplegia, and quadriplegia ( p < 0.0001, 95% CI 1.506-2.778). No significant difference was found in prematurity, GMFCS levels, MACS levels, and the number of comorbidities.<br />Conclusions: Normal MRIs were associated with lack of perinatal adversity as well as with the dyskinetic, ataxic/hypotonic, and spastic diplegic CP subtypes. As MRI normality is not strongly associated with the severity of CP, continuous follow-up in children with normal imaging appears warranted. Further advanced imaging modalities, as well as strong consideration for metabolic and genetic testing, may provide additional insights into causal pathways in this population.<br /> (© 2019 American Academy of Neurology.)
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 93
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 31127072
- Full Text :
- https://doi.org/10.1212/WNL.0000000000007726