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Dual functional monomers modified magnetic adsorbent for the enrichment of non-steroidal anti-inflammatory drugs in water and urine samples.
- Source :
-
Talanta [Talanta] 2019 Aug 15; Vol. 201, pp. 496-502. Date of Electronic Publication: 2019 Apr 22. - Publication Year :
- 2019
-
Abstract
- According to the molecular properties of non-steroidal anti-inflammatory drugs (NSADs), a new adsorbent for magnetic solid phase extraction (MSPE) was designed and synthesized. Triethyl-(4-vinylbenzyl)aminium chloride and 4-vinylbenzeneboronic acid were utilized as dual functional monomers to copolymerize with divinylbenzene on the surface of pre-modified Fe <subscript>3</subscript> O <subscript>4</subscript> nanoparticles. The prepared magnetic adsorbent (Fe <subscript>3</subscript> O <subscript>4</subscript> @TCVA) was characterized by elemental analysis, Fourier transform infrared, scanning electron microscopy, transmission electron microscopy and vibrating sample magnetometer. Due to the abundant boronic acid, quaternary amine and phenyl groups, the Fe <subscript>3</subscript> O <subscript>4</subscript> @TCVA displayed satisfactory extraction performance for target NSADs (diclofenac acid, ibuprofen and mefenamic acid) by means of B-N coordination, anion-exchange, π-π and hydrophobic interactions. Under the optimized conditions, the Fe <subscript>3</subscript> O <subscript>4</subscript> @TCVA/MSPE was combined with high-performance liquid chromatography with diode array detection (HPLC-DAD) to sensitively analyze NSADs in water and human urine samples. Results indicated that the limits of detection for water and urine samples were in the ranges of 0.014-0.031 μg/L and 0.029-0.11 μg/L, respectively. The relative standard deviations for the intra-day and inter-day assay variability were below 10%. The applicability of the proposed Fe <subscript>3</subscript> O <subscript>4</subscript> @TCVA/MSPE-HPLC-DAD method was demonstrated by the successful extraction and quantification of trace levels of NSADs in real water and human urine samples. Satisfactory spiked recovery and reproducibility were achieved.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adsorption
Drinking Water analysis
Humans
Lakes analysis
Limit of Detection
Magnetite Nanoparticles chemistry
Polymerization
Polyvinyls chemical synthesis
Polyvinyls chemistry
Reproducibility of Results
Sodium Chloride chemistry
Wastewater analysis
Water Pollutants, Chemical analysis
Anti-Inflammatory Agents, Non-Steroidal urine
Diclofenac urine
Ibuprofen urine
Mefenamic Acid urine
Solid Phase Extraction methods
Vinyl Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3573
- Volume :
- 201
- Database :
- MEDLINE
- Journal :
- Talanta
- Publication Type :
- Academic Journal
- Accession number :
- 31122456
- Full Text :
- https://doi.org/10.1016/j.talanta.2019.04.043