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Protection of cholinergic and antioxidant system contributes to the effect of Vitamin D 3 ameliorating memory dysfunction in sporadic dementia of Alzheimer's type.
- Source :
-
Redox report : communications in free radical research [Redox Rep] 2019 Dec; Vol. 24 (1), pp. 34-40. - Publication Year :
- 2019
-
Abstract
- Objective: Investigate Vitamin D <subscript>3</subscript> (VD <subscript>3</subscript> ) effect on the Acetylcholinesterase (AChE), oxidative damage and behavioral tests in animals subjected to Intracerebroventicular injection of Streptozotocin (ICV-STZ) simulating a Sporadic Dementia of Alzheimer's Type (SDAT) and treated with VD <subscript>3</subscript> (21 days).<br />Methods: Animals were divided into eight groups: Vehicle, VD12.5 μg/kg, VD42 μg/kg, VD125 μg/kg, STZ, STZ+VD12.5 μg/kg, STZ+VD42 μg/kg, STZ+VD125 μg/kg.<br />Results: VD <subscript>3</subscript> prevented the increase in AChE in groups of VD42 µg/kg and VD125 µg/kg; in AChE of synaptossomes and TBARS levels prevented the increase in group VD125 µg/kg; in ROS levels there was not a significant difference; for the Carbonyl Content all doses prevented the increase. Total Thiols prevent the decrease in VD42 µg/kg and VD125 µg/kg, and Reduced Glutathione prevented the decrease in VD125 µg/kg, Oxidized Glutathione prevented the increase in VD125 µg/kg. In relation to behavioral tests, the VD <subscript>3</subscript> prevented the increase in time to find (days 2 and 3), in the time to find the platform (day 3) and in time spent in the quadrant (day 2). However, in relation to crossings there was not difference in groups. These results indicated the therapeutic effect of the VD <subscript>3</subscript> in model of STZ in rats.
- Subjects :
- Animals
Ascorbic Acid metabolism
Dementia metabolism
Disease Models, Animal
Lipid Peroxidation drug effects
Male
Memory drug effects
Oxidative Stress drug effects
Rats
Rats, Wistar
Reactive Oxygen Species metabolism
Acetylcholinesterase metabolism
Alzheimer Disease metabolism
Antioxidants metabolism
Cholecalciferol therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1743-2928
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Redox report : communications in free radical research
- Publication Type :
- Academic Journal
- Accession number :
- 31100998
- Full Text :
- https://doi.org/10.1080/13510002.2019.1617514