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Antimicrobial blue light inactivation of international clones of multidrug-resistant Escherichia coli ST10, ST131 and ST648.
- Source :
-
Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2019 Sep; Vol. 27, pp. 51-53. Date of Electronic Publication: 2019 May 14. - Publication Year :
- 2019
-
Abstract
- Background: International clones of multidrug-resistant Escherichia coli have been a leading cause of human and animal infections worldwide. Microbial inactivation by blue light has been proposed as an effective treatment for superficial infections and surface contamination.<br />Aim: To evaluate the inactivation efficacy of blue light irradiation against high-risk multidrug-resistant strains of E. coli.<br />Methods: Blue LED light (λ = 410 nm) was used to inactivate in vitro suspensions of colistin- broad-spectrum cephalosporin-, or carbapenem-resistant E. coli strains belonging to sequence types (STs) ST10, ST131 and ST648, carrying mcr-1, bla <subscript>CTX-M</subscript> or bla <subscript>KPC-2</subscript> genes.<br />Results: Our results showed that all E. coli strains were susceptible to blue light irradiation, independently of antibiotic resistance and virulence profiles. In addition, blue light irradiation induced a strain-specific and dose-dependent bacterial effect.<br />Conclusion: Our results support use of blue light as a promising antimicrobial option against MDR pathogens, including high-risk clones of E. coli displaying resistance to polymyxins or broad-spectrum β-lactam antibiotics.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-1597
- Volume :
- 27
- Database :
- MEDLINE
- Journal :
- Photodiagnosis and photodynamic therapy
- Publication Type :
- Academic Journal
- Accession number :
- 31100445
- Full Text :
- https://doi.org/10.1016/j.pdpdt.2019.05.014