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Classification of Strokes in Patients Receiving Intravitreal Anti-Vascular Endothelial Growth Factor.
- Source :
-
Ophthalmic surgery, lasers & imaging retina [Ophthalmic Surg Lasers Imaging Retina] 2019 May 01; Vol. 50 (5), pp. e140-e157. - Publication Year :
- 2019
-
Abstract
- Background and Objective: The purpose of this study was to identify the differences in the types of strokes seen in patients receiving intravitreal anti-vascular endothelial growth factor (VEGF) compared with normal control populations.<br />Patients and Methods: We performed a retrospective consecutive review of all patients receiving intravitreal anti-VEGF injections in Olmsted County, Minnesota, from January 1, 2004, to December 31, 2013, for exudative age-related macular degeneration (AMD), diabetic macular edema (DME), proliferative diabetic retinopathy (PDR), or retinal vein occlusion (RVO). A 2-year follow-up period was required for study inclusion. Three age- and sex-matched cohorts were identified.<br />Results: A total of 2,541 patients were examined. There were 690 patients identified during the study period as receiving an intravitreal injection for AMD, DME, PDR, or RVO. Of these patients, 38 (5.8%) suffered a stroke after starting intravitreal injection therapy. Of these strokes, 27 (71.1%) were ischemic, six (15.8%) were embolic, and five (13.2%) were hemorrhagic. There were no differences in the types of strokes identified among the patients receiving intravitreal injections between the case cohort and the control cohorts (P > .05 for all).<br />Conclusion: The authors' data suggest there is no predilection to the development of ischemic infarcts or hemorrhagic strokes in those patients receiving intravitreal anti-VEGF compared with control populations. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e140-e157.].<br /> (Copyright 2019, SLACK Incorporated.)
- Subjects :
- Aged
Angiogenesis Inhibitors administration & dosage
Aptamers, Nucleotide administration & dosage
Aptamers, Nucleotide adverse effects
Bevacizumab administration & dosage
Bevacizumab adverse effects
Dihydropyridines
Female
Follow-Up Studies
Humans
Intravitreal Injections adverse effects
Male
Middle Aged
Ranibizumab administration & dosage
Receptors, Vascular Endothelial Growth Factor administration & dosage
Recombinant Fusion Proteins administration & dosage
Recombinant Fusion Proteins adverse effects
Retrospective Studies
Stroke chemically induced
Vascular Endothelial Growth Factor A antagonists & inhibitors
Angiogenesis Inhibitors adverse effects
Retinal Diseases drug therapy
Stroke classification
Subjects
Details
- Language :
- English
- ISSN :
- 2325-8179
- Volume :
- 50
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ophthalmic surgery, lasers & imaging retina
- Publication Type :
- Academic Journal
- Accession number :
- 31100168
- Full Text :
- https://doi.org/10.3928/23258160-20190503-14