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Evolving Landscape of Systemic Therapy for Hepatocellular Carcinoma: Breakthroughs, Toxicities, and Future Frontiers.
- Source :
-
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting [Am Soc Clin Oncol Educ Book] 2019 Jan; Vol. 39, pp. 248-260. Date of Electronic Publication: 2019 May 17. - Publication Year :
- 2019
-
Abstract
- The incidence and death rates of hepatocellular carcinoma (HCC) are rising. For more than a decade, the multikinase inhibitor sorafenib was the only U.S. Food and Drug Administration (FDA)-approved systemic therapy for HCC. However, since 2017, five additional agents have been approved in the first- or second-line setting. Although this represents an incredible victory for the field, there are no clear guidelines for agent selection on the basis of either patient or tumor characteristics. Here, we review the available systemic therapy options for advanced HCC and reported clinical data for each. We outline each agent's unique toxicity profile, potential impact on patient quality of life, monitoring recommendations, and supportive strategies. Last, we review molecular and immunologic classifications of HCC as well as preclinical data that may serve as a basis for future biomarker enriched clinical trials to enable precision oncology care in HCC.
- Subjects :
- Animals
Biomarkers, Tumor
Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular etiology
Carcinoma, Hepatocellular mortality
Clinical Trials as Topic
Combined Modality Therapy adverse effects
Combined Modality Therapy methods
Disease Management
Humans
Liver Neoplasms diagnosis
Liver Neoplasms etiology
Liver Neoplasms mortality
Molecular Targeted Therapy adverse effects
Molecular Targeted Therapy methods
Neoplasm Metastasis
Neoplasm Staging
Precision Medicine
Prognosis
Treatment Outcome
Carcinoma, Hepatocellular therapy
Liver Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1548-8756
- Volume :
- 39
- Database :
- MEDLINE
- Journal :
- American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
- Publication Type :
- Academic Journal
- Accession number :
- 31099615
- Full Text :
- https://doi.org/10.1200/EDBK_237555