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Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study.
- Source :
-
Anticancer research [Anticancer Res] 2019 May; Vol. 39 (5), pp. 2513-2517. - Publication Year :
- 2019
-
Abstract
- Background/aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma.<br />Patients and Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39.1%) patients had squamous cell carcinoma, five (21.7%) had a thyroid carcinoma, six (26.1%) had a carcinoid, one (4.3%) patient had papillary renal carcinoma, one (4.3%) had medulloblastoma and one (4.3%) had intestinal-type mucinous adenocarcinoma.<br />Results: All six patients with stage I squamous cell carcinoma had no evidence of disease (NED) after a median time of 141 months. Of the three patients with stage IIb-IIIc squamous cell carcinoma, two had NED after 119 and 154 months, and one died of the disease 9 months after diagnosis. All five women with stage I thyroid carcinoma had NED after a median of 60 months. Of the six patients with stage I carcinoid, five had NED after a median of 168 months, whereas one died due to carcinoid heart disease. The three patients with stage I renal carcinoma, medulloblastoma and mucinous adenocarcinoma had NED after 24, 141 and 149 months, respectively.<br />Conclusion: The clinical outcome of early-stage malignancies associated with mature ovarian teratomas is excellent following treatment.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adult
Aged
Carcinoid Tumor diagnosis
Carcinoid Tumor pathology
Carcinoid Tumor surgery
Carcinoma, Renal Cell diagnosis
Carcinoma, Renal Cell epidemiology
Carcinoma, Renal Cell pathology
Carcinoma, Renal Cell surgery
Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell surgery
Female
Humans
Medulloblastoma diagnosis
Medulloblastoma epidemiology
Medulloblastoma pathology
Medulloblastoma surgery
Middle Aged
Neoplasm Staging
Ovarian Neoplasms classification
Ovarian Neoplasms diagnosis
Ovarian Neoplasms surgery
Retrospective Studies
Teratoma diagnosis
Teratoma epidemiology
Teratoma surgery
Thyroid Neoplasms diagnosis
Thyroid Neoplasms epidemiology
Thyroid Neoplasms surgery
Carcinoid Tumor epidemiology
Ovarian Neoplasms pathology
Teratoma pathology
Thyroid Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 39
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 31092447
- Full Text :
- https://doi.org/10.21873/anticanres.13372