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Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score.
- Source :
-
Circulation. Cardiovascular quality and outcomes [Circ Cardiovasc Qual Outcomes] 2019 May; Vol. 12 (5), pp. e005358. - Publication Year :
- 2019
-
Abstract
- Background The Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire has recently been validated to measure the impact of atrial fibrillation on quality of life, but a clinically important difference in AFEQT score has not been well defined. Methods and Results To determine the clinically important difference in overall AFEQT (score range= 0 [worst] to 100 [best]) and selected subscales, we analyzed data in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry, a United States-based outpatient atrial fibrillation registry. AFEQT was assessed at baseline and 1 year in a subset of 1347 ORBIT-AF patients from 80 US sites participating in ORBIT-AF from June 2010 to August 2011. The mean change method was used to relate changes in 1-year AFEQT scores to clinically important changes in the physician assessment of European Heart Rhythm Association functional status (1 class improvement and separately 1 class deterioration). Clinically important differences and 95% CI corresponding to either a 1 European Heart Rhythm Association class improvement or deterioration were 5.4 (3.6-7.2) and -4.2 (-6.9 to -1.5) AFEQT points, respectively. Similarly, clinically important difference values were seen for a 1 European Heart Rhythm Association class improvement for the AFEQT subscales Activities of Daily Living and Symptoms: 5.1 (2.5-7.6) and 7.1 (5.3-9.0) AFEQT points, respectively. Conclusions Based on the anchor of 1 European Heart Rhythm Association class change, changes in AFEQT score of + or -5 points are clinically important changes in patients' health. Clinical Trial Registration URL: https://clinicaltrials.gov . Unique identifier: NCT01165710.
- Subjects :
- Aged
Aged, 80 and over
Atrial Fibrillation physiopathology
Atrial Fibrillation psychology
Atrial Fibrillation therapy
Cost of Illness
Disease Progression
Female
Humans
Male
Predictive Value of Tests
Recovery of Function
Registries
Time Factors
Treatment Outcome
United States
Atrial Fibrillation diagnosis
Minimal Clinically Important Difference
Quality of Life
Surveys and Questionnaires
Subjects
Details
- Language :
- English
- ISSN :
- 1941-7705
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Circulation. Cardiovascular quality and outcomes
- Publication Type :
- Academic Journal
- Accession number :
- 31092022
- Full Text :
- https://doi.org/10.1161/CIRCOUTCOMES.118.005358