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Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin.
- Source :
-
Journal of integrative neuroscience [J Integr Neurosci] 2019 Mar 30; Vol. 18 (1), pp. 43-49. - Publication Year :
- 2019
-
Abstract
- Hippocampal neurogenesis plays an important role in the onset and treatment of depressive disorders. Previous studies suggest that paeoniflorin could be used as an antidepressant for treating rats subjected to chronic unpredictable stress. In this study, the effects of paeoniflorin on neurogenesis in the hippocampus dentate gyrus and potential mechanism of action are further investigated in chronic unpredictable stress-induced rat. Results suggest that paeoniflorin markedly increased both sucrose consumption and the number of 5-bromo-2-deoxyuridine-positive cells in the dentate gyrus of chronic unpredictable stress-induced rats, and the ratio of co-expressed 5-bromo-2-deoxyuridine and glial fibrillary acidic protein-positive cells, but exerted no significant effect on the ratio of co-expressed 5-bromo-2-deoxyuridine and neuronal nuclei-positive cells. Compared with the vehicle group, a significant increase was detected in the number of brain-derived neurotrophic factor-positive cells and the expression of brain-derived neurotrophic factor mRNA in the hippocampus of the paeoniflorin-treated group. According to the results, paeoniflorin promoted neural stem cell proliferation, their differentiation into astrocytes, and neurogenesis in the hippocampal dentate gyrus of chronic unpredictable stress-induced rats. Apart from enhancing the protein expression and gene transcription of brain-derived neurotrophic factor, it also activated the expression of tropomyosin receptor kinase B (a high-affinity receptor of brain-derived neurotrophic factor). This suggests that paeoniflorin might promote neurogenesis in the hippocampus dentate gyrus of chronic unpredictable stress-induced rats and act as an antidepressant by regulating the brain-derived neurotrophic factor-tropomyosin receptor kinase B signaling pathway.<br />Competing Interests: Authors report no confict of interest.<br /> (© 2019 Chen et al. Published by IMR press. All rights reserved.)
- Subjects :
- Animals
Brain-Derived Neurotrophic Factor metabolism
Chronic Disease
Dentate Gyrus physiopathology
Depressive Disorder physiopathology
Disease Models, Animal
Imipramine pharmacology
Male
Neurogenesis physiology
RNA, Messenger metabolism
Random Allocation
Rats, Sprague-Dawley
Receptor, trkB metabolism
Stress, Psychological drug therapy
Stress, Psychological physiopathology
Uncertainty
Antidepressive Agents pharmacology
Dentate Gyrus drug effects
Depressive Disorder drug therapy
Glucosides pharmacology
Monoterpenes pharmacology
Neurogenesis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0219-6352
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of integrative neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 31091847
- Full Text :
- https://doi.org/10.31083/j.jin.2019.01.116