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The Metabolic Basis of Kidney Cancer.

Authors :
Linehan WM
Schmidt LS
Crooks DR
Wei D
Srinivasan R
Lang M
Ricketts CJ
Source :
Cancer discovery [Cancer Discov] 2019 Aug; Vol. 9 (8), pp. 1006-1021. Date of Electronic Publication: 2019 May 14.
Publication Year :
2019

Abstract

Kidney cancer is not a single disease but represents several distinct types of cancer that have defining histologies and genetic alterations and that follow different clinical courses and have different responses to therapy. Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB , dysregulates the tumor's responses to changes in oxygen, iron, nutrient, or energy levels. The identification of these varying genetic bases of kidney cancer has increased our understanding of the biology of this cancer, allowing the development of targeted therapies and the appreciation that it is a cancer driven by metabolic alterations. SIGNIFICANCE: Kidney cancer is a complex disease composed of different types of cancer that present with different histologies, clinical courses, genetic changes, and responses to therapy. This review describes the known genetic changes within kidney cancer, how they alter tumor metabolism, and how these metabolic changes can be therapeutically targeted.<br /> (©2019 American Association for Cancer Research.)

Details

Language :
English
ISSN :
2159-8290
Volume :
9
Issue :
8
Database :
MEDLINE
Journal :
Cancer discovery
Publication Type :
Academic Journal
Accession number :
31088840
Full Text :
https://doi.org/10.1158/2159-8290.CD-18-1354