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The Metabolic Basis of Kidney Cancer.
- Source :
-
Cancer discovery [Cancer Discov] 2019 Aug; Vol. 9 (8), pp. 1006-1021. Date of Electronic Publication: 2019 May 14. - Publication Year :
- 2019
-
Abstract
- Kidney cancer is not a single disease but represents several distinct types of cancer that have defining histologies and genetic alterations and that follow different clinical courses and have different responses to therapy. Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB , dysregulates the tumor's responses to changes in oxygen, iron, nutrient, or energy levels. The identification of these varying genetic bases of kidney cancer has increased our understanding of the biology of this cancer, allowing the development of targeted therapies and the appreciation that it is a cancer driven by metabolic alterations. SIGNIFICANCE: Kidney cancer is a complex disease composed of different types of cancer that present with different histologies, clinical courses, genetic changes, and responses to therapy. This review describes the known genetic changes within kidney cancer, how they alter tumor metabolism, and how these metabolic changes can be therapeutically targeted.<br /> (©2019 American Association for Cancer Research.)
- Subjects :
- Animals
Biomarkers
Carcinoma, Renal Cell genetics
Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell pathology
Cell Transformation, Neoplastic genetics
Cell Transformation, Neoplastic metabolism
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Kidney Neoplasms pathology
Kidney Neoplasms therapy
Mitochondria metabolism
Mutation
Oxygen metabolism
Signal Transduction
Disease Susceptibility
Energy Metabolism
Kidney Neoplasms genetics
Kidney Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2159-8290
- Volume :
- 9
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer discovery
- Publication Type :
- Academic Journal
- Accession number :
- 31088840
- Full Text :
- https://doi.org/10.1158/2159-8290.CD-18-1354