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Does secretin influence rat colonic absorption and secretion?
- Source :
-
The American journal of gastroenterology [Am J Gastroenterol] 1978 Sep; Vol. 70 (3), pp. 265-9. - Publication Year :
- 1978
-
Abstract
- In rats, a secretin (Jorpes) intravenous infusion superimposed on an intracolonic sodium acetate perfusion elicits, with respect to control values, a significant depression of Na+ absorption (0.16 mEq./h-0.00 mEq./h.) and mucus secretion (230-40 mg.). When the hormone is superimposed upon an intracolonic infusion of acetic acid, mucus secretion is also significantly inhibited (790-340 mg.). The influence of secretin on organic anion movement was pH related. At pH values of 7.0, absorption was unchanged (0.34--0.33 mEq./h.), at pH values of 2.9, absorption was significantly reduced (0.67-0.41 mEq./h). The secretin impairment of colonic mucus secretion could influence the transport of watersoluble (Na+) and lipid soluble (acetic acid) substances, probably through changes at the "unstirred layer" level.
- Subjects :
- Acetates
Animals
Colon drug effects
Hydrogen-Ion Concentration
Infusions, Parenteral
Intestinal Mucosa drug effects
Male
Rats
Secretin administration & dosage
Secretin pharmacology
Sodium metabolism
Colon metabolism
Intestinal Absorption drug effects
Intestinal Mucosa metabolism
Mucus metabolism
Secretin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9270
- Volume :
- 70
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 31088