Back to Search
Start Over
Research progress on the pathogenesis of CTEPH.
- Source :
-
Heart failure reviews [Heart Fail Rev] 2019 Nov; Vol. 24 (6), pp. 1031-1040. - Publication Year :
- 2019
-
Abstract
- Chronic thromboembolic pulmonary hypertension (CTEPH) is an established long-term complication of pulmonary thromboembolism (PTE). However, studies have shown that many patients with a definitive CTEPH diagnosis have no history of symptomatic PTE, suggesting that PTE is not the only cause of CTEPH. Despite extensive progress in research on pulmonary hypertension in recent years, due to a lack of relevant studies on the pathophysiology of CTEPH, implementing pulmonary endarterectomy (PEA) in patients has many challenges, and the prognosis of patients with CTEPH is still not optimistic. Therefore, revealing the pathogenesis of CTEPH would be of great significance for understanding the occurrence and development of CTEPH, developing relevant drug treatment studies and formulating intervention strategies, and may provide new preventive measures. This article summarizes the current research progress in CTEPH pathogenesis from the perspective of risk factors related to medical history, abnormal coagulation and fibrinolytic mechanisms, inflammatory mechanisms, genetic susceptibility factors, angiogenesis, in situ thrombosis, vascular remodeling, and other aspects.
- Subjects :
- Animals
Blood Coagulation Disorders physiopathology
Chronic Disease
Fibrinolysis physiology
Genetic Predisposition to Disease genetics
Humans
Inflammation physiopathology
Mice
Models, Animal
Neovascularization, Pathologic physiopathology
Prognosis
Prospective Studies
Pulmonary Embolism epidemiology
Pulmonary Embolism mortality
Pulmonary Embolism surgery
Risk Factors
Vascular Remodeling physiology
Endarterectomy adverse effects
Hypertension, Pulmonary complications
Pulmonary Artery physiopathology
Pulmonary Embolism physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7322
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Heart failure reviews
- Publication Type :
- Academic Journal
- Accession number :
- 31087212
- Full Text :
- https://doi.org/10.1007/s10741-019-09802-4