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Drug repurposing to overcome resistance to various therapies for colorectal cancer.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 Sep; Vol. 76 (17), pp. 3383-3406. Date of Electronic Publication: 2019 May 13. - Publication Year :
- 2019
-
Abstract
- Emergence of novel treatment modalities provides effective therapeutic options, apart from conventional cytotoxic chemotherapy, to fight against colorectal cancer. Unfortunately, drug resistance remains a huge challenge in clinics, leading to invariable occurrence of disease progression after treatment initiation. While novel drug development is unfavorable in terms of time frame and costs, drug repurposing is one of the promising strategies to combat resistance. This approach refers to the application of clinically available drugs to treat a different disease. With the well-established safety profile and optimal dosing of these approved drugs, their combination with current cancer therapy is suggested to provide an economical, safe and efficacious approach to overcome drug resistance and prolong patient survival. Here, we review both preclinical and clinical efficacy, as well as cellular mechanisms, of some extensively studied repurposed drugs, including non-steroidal anti-inflammatory drugs, statins, metformin, chloroquine, disulfiram, niclosamide, zoledronic acid and angiotensin receptor blockers. The three major treatment modalities in the management of colorectal cancer, namely classical cytotoxic chemotherapy, molecular targeted therapy and immunotherapy, are covered in this review.
- Subjects :
- Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Antimetabolites chemistry
Antimetabolites pharmacology
Antimetabolites therapeutic use
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents, Immunological pharmacology
Antineoplastic Agents, Immunological therapeutic use
Colorectal Neoplasms pathology
Humans
Protein Kinase Inhibitors chemistry
Protein Kinase Inhibitors pharmacology
Protein Kinase Inhibitors therapeutic use
Topoisomerase I Inhibitors chemistry
Topoisomerase I Inhibitors pharmacology
Topoisomerase I Inhibitors therapeutic use
Antineoplastic Agents therapeutic use
Colorectal Neoplasms drug therapy
Drug Repositioning
Drug Resistance, Neoplasm drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 76
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 31087119
- Full Text :
- https://doi.org/10.1007/s00018-019-03134-0