Inhibition of ADP-ribosylation of histone H1 by analogs of diadenosine 5',5'''-p1,p4-tetraphosphate.

Authors :: Suzuki H
Tanaka Y
Buonamassa DT
Farina B
Leone E
Source :: Molecular and cellular biochemistry [Mol Cell Biochem] 1987 Mar; Vol. 74 (1), pp. 17-20.
Publication Year :: 1987
Abstract: The effects of analogs of diadenosine 5',5'''-p1,p4-tetraphosphate (Ap4A) were examined on the ADP-ribosylation reaction of histone H1 catalysed by purified bovine thymus poly(ADP-ribose)transferase. Among the compounds tested, epsilon Ap4A and ApCH2pppA were shown to be the most efficient inhibitors of the enzyme. From kinetic studies of their action, it appears that epsilon Ap4A and ApCH2pppA might be 'mixed type' inhibitors.

Subjects :: Animals
Cattle
Kinetics
Structure-Activity Relationship
Thymus Gland enzymology
Adenine Nucleotides pharmacology
Adenosine Diphosphate Ribose metabolism
Dinucleoside Phosphates
Histones metabolism
Poly(ADP-ribose) Polymerase Inhibitors

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