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Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent.
Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent.
- Source :
-
Nature communications [Nat Commun] 2019 May 13; Vol. 10 (1), pp. 2133. Date of Electronic Publication: 2019 May 13. - Publication Year :
- 2019
-
Abstract
- Polycomb (PcG) and Trithorax (TrxG) group proteins give stable epigenetic memory of silent and active gene expression states, but also allow poised states in pluripotent cells. Here we systematically address the relationship between poised, active and silent chromatin, by integrating 73 publications on PcG/TrxG biochemistry into a mathematical model comprising 144 nucleosome modification states and 8 enzymatic reactions. Our model predicts that poised chromatin is bistable and not bivalent. Bivalent chromatin, containing opposing active and silent modifications, is present as an unstable background population in all system states, and different subtypes co-occur with active and silent chromatin. In contrast, bistability, in which the system switches frequently between stable active and silent states, occurs under a wide range of conditions at the transition between monostable active and silent system states. By proposing that bistability and not bivalency is associated with poised chromatin, this work has implications for understanding the molecular nature of pluripotency.
- Subjects :
- Chromosomal Proteins, Non-Histone metabolism
Drosophila Proteins metabolism
Enzymes metabolism
Histone Code physiology
Histone-Lysine N-Methyltransferase metabolism
Histones metabolism
Myeloid-Lymphoid Leukemia Protein metabolism
Nucleosomes metabolism
Chromatin metabolism
Epigenesis, Genetic physiology
Models, Biological
Polycomb-Group Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 31086177
- Full Text :
- https://doi.org/10.1038/s41467-019-10130-2