Phylogenomic Investigation of IncI1-Iγ Plasmids Harboring bla CMY-2 and bla SHV-12 in Salmonella enterica and Escherichia coli in Multiple Countries.

Authors :: Castellanos LR
van der Graaf-van Bloois L
Donado-Godoy P
Mevius DJ
Wagenaar JA
Hordijk J
Zomer AL
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Jun 24; Vol. 63 (7). Date of Electronic Publication: 2019 Jun 24 (Print Publication: 2019).
Publication Year :: 2019
Abstract: The objective of this study was to elucidate the genetic and evolutionary relatedness of bla <subscript>CMY-2</subscript> - and bla <subscript>SHV-12</subscript> -carrying IncI1-Iγ plasmids. Phylogenomic analysis based on core genome alignments and gene presence/absence was performed for different IncI1-Iγ sequence types (STs). Most IncI1-Iγ/ST12 and IncI1-Iγ/ST231 plasmids had near-identical core genomes. The data suggest that widely occurring bla <subscript>CMY-2</subscript> -carrying IncI1-Iγ/ST12 plasmids originate from a common ancestor. In contrast, bla <subscript>SHV-12</subscript> was inserted independently into different IncI1-Iγ/ST231-related plasmids.<br /> (Copyright © 2019 American Society for Microbiology.)

Subjects :: Phylogeny
Escherichia coli genetics
Plasmids genetics
Salmonella enterica genetics
beta-Lactamases genetics

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