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Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 Jun 30; Vol. 514 (3), pp. 919-925. Date of Electronic Publication: 2019 May 10. - Publication Year :
- 2019
-
Abstract
- Staphylococcal nuclease and tudor domain containing 1 (SND1) has multiple functions in a variety of cellular processes. Here, we assessed the effects of SND1 in cellular DNA damage after ionizing radiation (IR). Knocking down SND1 in the mouse-derived photoreceptor 661 W cell line markedly inhibited cell proliferation and increased apoptosis after IR treatment. After DNA damage, SND1 induced Ataxia telangiectasia mutated kinase (ATM) signaling to launch DNA repair. Defects of SND1 were associated with missing response to DNA damage signal to cell cycle checkpoints or DNA repair. The current findings reveal SND1 as a new regulatory factor in DNA damage response.<br /> (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Apoptosis genetics
Apoptosis radiation effects
Ataxia Telangiectasia Mutated Proteins genetics
Ataxia Telangiectasia Mutated Proteins metabolism
Cell Line, Tumor
Cell Proliferation radiation effects
Comet Assay
DNA metabolism
DNA Breaks, Double-Stranded radiation effects
Endonucleases deficiency
G2 Phase Cell Cycle Checkpoints genetics
Gamma Rays
Gene Expression Regulation
Gene Knockdown Techniques
Histones genetics
Histones metabolism
Mice
Retinal Cone Photoreceptor Cells cytology
Retinal Cone Photoreceptor Cells metabolism
Signal Transduction
Ultraviolet Rays
DNA genetics
DNA Repair drug effects
Endonucleases genetics
G2 Phase Cell Cycle Checkpoints radiation effects
Retinal Cone Photoreceptor Cells radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 514
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 31084926
- Full Text :
- https://doi.org/10.1016/j.bbrc.2019.04.189