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Mass cytometry reveals an impairment of B cell homeostasis in anti-synthetase syndrome.

Authors :
Dzangué-Tchoupou G
Allenbach Y
Preuße C
Stenzel W
Benveniste O
Source :
Journal of neuroimmunology [J Neuroimmunol] 2019 Jul 15; Vol. 332, pp. 212-215. Date of Electronic Publication: 2019 Apr 29.
Publication Year :
2019

Abstract

Recent data suggest the implication of T, B and NK cells in the anti-synthetase syndrome (ASyS); nevertheless their role and activation states are poorly described. We performed deep immune-profiling using 37 markers on peripheral blood cells from 10 ASyS patients versus 17 healthy donors (HD) and 26 myositis control patients. We show decreased percentages of memory B cells in ASyS patients (mean ± SEM: ASyS = 13 ± 3%, HD = 37 ± 4% and 'myositis controls' = 32 ± 3), counterbalanced by increased percentages of naïve B cells. Interestingly, perifascicular infiltrations of memory B cells within muscle biopsies of ASyS patients suggest that they niche within the muscle.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-8421
Volume :
332
Database :
MEDLINE
Journal :
Journal of neuroimmunology
Publication Type :
Academic Journal
Accession number :
31082769
Full Text :
https://doi.org/10.1016/j.jneuroim.2019.04.014