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Mass cytometry reveals an impairment of B cell homeostasis in anti-synthetase syndrome.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2019 Jul 15; Vol. 332, pp. 212-215. Date of Electronic Publication: 2019 Apr 29. - Publication Year :
- 2019
-
Abstract
- Recent data suggest the implication of T, B and NK cells in the anti-synthetase syndrome (ASyS); nevertheless their role and activation states are poorly described. We performed deep immune-profiling using 37 markers on peripheral blood cells from 10 ASyS patients versus 17 healthy donors (HD) and 26 myositis control patients. We show decreased percentages of memory B cells in ASyS patients (mean ± SEM: ASyS = 13 ± 3%, HD = 37 ± 4% and 'myositis controls' = 32 ± 3), counterbalanced by increased percentages of naïve B cells. Interestingly, perifascicular infiltrations of memory B cells within muscle biopsies of ASyS patients suggest that they niche within the muscle.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Algorithms
Antigens, CD analysis
B-Lymphocyte Subsets pathology
CD8-Positive T-Lymphocytes immunology
Dermatomyositis immunology
Female
Humans
Immunologic Memory
Killer Cells, Natural immunology
Male
Middle Aged
Muscle, Skeletal immunology
Antibodies, Antinuclear immunology
Autoimmune Diseases immunology
B-Lymphocyte Subsets immunology
Flow Cytometry methods
Histidine-tRNA Ligase immunology
Immunophenotyping
Lung Diseases, Interstitial immunology
Myositis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 332
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 31082769
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2019.04.014