Back to Search
Start Over
Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease.
- Source :
-
Behavioural brain research [Behav Brain Res] 2019 Sep 16; Vol. 370, pp. 111932. Date of Electronic Publication: 2019 May 10. - Publication Year :
- 2019
-
Abstract
- The role of mitochondrial dysfunction has been well-documented in Alzheimer's disease (AD). Glucagon-like peptide 1 (GLP-1) receptor agonists are being utilized as neuroprotectants in the treatment of various neurological disorders, including AD. We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice. Spatial memory test showed that exenatide administration (100 μg/kg twice per day) prevented cognitive decline after 16 weeks of treatment. Aβ <subscript>1-42</subscript> deposition and synapse damage in the hippocampus was significantly alleviated. Furthermore, exenatide treatment can improve mitochondrial morphology, relieve oxidative damage, correct mitochondrial energy crisis, and normalize mitochondrial dynamics. These findings suggest that exenatide, which has already been applied in clinical medicine, may be a promising agent for AD therapy via mitochondrial protection.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Amyloid beta-Peptides metabolism
Amyloid beta-Protein Precursor metabolism
Animals
Brain metabolism
Disease Models, Animal
Exenatide metabolism
Glucagon-Like Peptide 1 metabolism
Glucagon-Like Peptide-1 Receptor agonists
Hippocampus metabolism
Male
Memory physiology
Mice
Mice, Inbred Strains
Mice, Transgenic
Mitochondria drug effects
Neuroprotective Agents pharmacology
Plaque, Amyloid metabolism
Synapses metabolism
Alzheimer Disease metabolism
Cognitive Dysfunction drug therapy
Exenatide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 370
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 31082410
- Full Text :
- https://doi.org/10.1016/j.bbr.2019.111932