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Clinical and angiographic outcomes of bioabsorbable vs. permanent polymer drug-eluting stents in Sweden: a report from the Swedish Coronary and Angioplasty Registry (SCAAR).
- Source :
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European heart journal [Eur Heart J] 2019 Aug 14; Vol. 40 (31), pp. 2607-2615. - Publication Year :
- 2019
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Abstract
- Aims: Randomized clinical trials have consistently demonstrated the non-inferiority of bioabsorbable polymer drug-eluting stents (BP-DES) with respect to DES having permanent polymers (PP-DES). To date, the comparative performance of BP- and PP-DES in the real world has not been extensively investigated.<br />Methods and Results: From October 2011 to June 2016, we analysed the outcomes associated with newer generation DES use in Sweden. After stratification according to the type of DES received at the index procedure, a total of 16 504 and 79 106 stents were included in the BP- and PP-DES groups, respectively. The Kaplan-Meier estimates for restenosis at 2 years were 1.2% and 1.4% in BP- and PP-DES groups, respectively. Definite stent thrombosis (ST) was low in both groups (0.5% and 0.7% in BP- and PP-DES groups, respectively). The adjusted hazard ratio (HR) for either restenosis or definite ST did not differ between BP- and PP-DES [adjusted HR 0.95, 95% confidence interval (CI) 0.74-1.21; P = 0.670 and adjusted HR 0.79, 95% CI 0.57-1.09; P = 0.151, respectively]. Similarly, there were no differences in the adjusted risk of all-cause death and myocardial infarction (MI) between the two groups (adjusted HR for all-cause death 1.01, 95% CI 0.82-1.25; P = 0.918 and adjusted HR for MI 1.05, 95% CI 0.93-1.19; P = 0.404).<br />Conclusion: In a large, nationwide, and unselected cohort of patients, percutaneous coronary intervention with BP-DES implantation was not associated with an incremental clinical benefit over PP-DES use at 2 years follow-up.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Absorbable Implants statistics & numerical data
Aged
Aged, 80 and over
Angioplasty, Balloon, Coronary methods
Cause of Death trends
Coronary Angiography methods
Coronary Restenosis epidemiology
Coronary Restenosis pathology
Drug-Eluting Stents statistics & numerical data
Humans
Middle Aged
Myocardial Infarction epidemiology
Myocardial Infarction mortality
Non-Randomized Controlled Trials as Topic
Percutaneous Coronary Intervention methods
Polymers
Prospective Studies
Prosthesis Design
Prosthesis Failure trends
Registries
Sweden epidemiology
Absorbable Implants adverse effects
Acute Coronary Syndrome therapy
Coronary Angiography statistics & numerical data
Coronary Artery Disease therapy
Drug-Eluting Stents adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1522-9645
- Volume :
- 40
- Issue :
- 31
- Database :
- MEDLINE
- Journal :
- European heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 31079155
- Full Text :
- https://doi.org/10.1093/eurheartj/ehz244