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Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC).
- Source :
-
NeuroImage. Clinical [Neuroimage Clin] 2019; Vol. 23, pp. 101846. Date of Electronic Publication: 2019 May 04. - Publication Year :
- 2019
-
Abstract
- Background: amyloid-PET reading has been classically implemented as a binary assessment, although the clinical experience has shown that the number of borderline cases is non negligible not only in epidemiological studies of asymptomatic subjects but also in naturalistic groups of symptomatic patients attending memory clinics. In this work we develop a model to compare and integrate visual reading with two independent semi-quantification methods in order to obtain a tracer-independent multi-parametric evaluation.<br />Methods: We retrospectively enrolled three cohorts of cognitively impaired patients submitted to <superscript>18</superscript> F-florbetaben (53 subjects), <superscript>18</superscript> F-flutemetamol (62 subjects), <superscript>18</superscript> F-florbetapir (60 subjects) PET/CT respectively, in 6 European centres belonging to the EADC. The 175 scans were visually classified as positive/negative following approved criteria and further classified with a 5-step grading as negative, mild negative, borderline, mild positive, positive by 5 independent readers, blind to clinical data. Scan quality was also visually assessed and recorded. Semi-quantification was based on two quantifiers: the standardized uptake value (SUVr) and the ELBA method. We used a sigmoid model to relate the grading with the quantifiers. We measured the readers accord and inconsistencies in the visual assessment as well as the relationship between discrepancies on the grading and semi-quantifications.<br />Conclusion: It is possible to construct a map between different tracers and different quantification methods without resorting to ad-hoc acquired cases. We used a 5-level visual scale which, together with a mathematical model, delivered cut-offs and transition regions on tracers that are (largely) independent from the population. All fluorinated tracers appeared to have the same contrast and discrimination ability with respect to the negative-to-positive grading. We validated the integration of both visual reading and different quantifiers in a more robust framework thus bridging the gap between a binary and a user-independent continuous scale.<br /> (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Alzheimer Disease epidemiology
Alzheimer Disease metabolism
Brain metabolism
Cohort Studies
Europe epidemiology
Female
Fluorine Radioisotopes metabolism
Humans
Male
Middle Aged
Plaque, Amyloid metabolism
Positron-Emission Tomography trends
Retrospective Studies
Alzheimer Disease diagnostic imaging
Brain diagnostic imaging
Plaque, Amyloid diagnostic imaging
Positron-Emission Tomography methods
Subjects
Details
- Language :
- English
- ISSN :
- 2213-1582
- Volume :
- 23
- Database :
- MEDLINE
- Journal :
- NeuroImage. Clinical
- Publication Type :
- Academic Journal
- Accession number :
- 31077984
- Full Text :
- https://doi.org/10.1016/j.nicl.2019.101846