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Nodal and distant metastases in sinonasal mucosal melanoma: A population-based analysis.

Authors :
Low CM
Price DL
Moore EJ
Stokken JK
Van Abel KM
Janus JR
Choby G
Source :
The Laryngoscope [Laryngoscope] 2020 Mar; Vol. 130 (3), pp. 622-627. Date of Electronic Publication: 2019 May 11.
Publication Year :
2020

Abstract

Objectives/hypothesis: Sinonasal mucosal melanoma (SNMM) is a rare malignant neoplasm. No study to date has analyzed the impact that nodal metastases and distant metastases at diagnosis have on overall survival (OS) and disease-specific survival (DSS).<br />Study Design: Retrospective database review.<br />Methods: The Surveillance, Epidemiology, and End Results database was queried for cases of SNMM. Descriptive statistics were used analyze patient demographic and clinicopathologic variables. The Kaplan-Meier model was used to analyze survival, and the Cox proportional hazards model was used for multivariate analysis.<br />Results: Three hundred twenty-eight cases of SNMM were identified. The most frequent sinonasal anatomic location was the nasal cavity in 279 (73.0%) patients, followed by the maxillary sinus in 60 (15.7%) patients. Regional nodal metastases at diagnosis occurred in 33 (8.6%) patients, whereas distant metastases at diagnosis occurred in 41 (10.7%) patients. Five-year OS was 22.7%, and 5-year DSS was 26.8%. The presence of positive nodes at diagnosis (OS P < .0001, DSS P < .0001), distant metastases at diagnosis (OS P = .0442, DSS P = .0442), primary tumor site (OS P < .0001, DSS P < .0001), and increasing age (OS P = .0012, DSS P = .0016) were found to be significant as negative predictors of OS and DSS.<br />Conclusions: SNMM is a rare pathologic entity with a poor prognosis. The presence of nodal and distant metastases at diagnosis are negative prognostic factors in OS and DSS. These factors can be used in the development of new models of risk stratification and to inform treatment strategies and surveillance patterns.<br />Level of Evidence: NA Laryngoscope, 130:622-627, 2020.<br /> (© 2019 The American Laryngological, Rhinological and Otological Society, Inc.)

Details

Language :
English
ISSN :
1531-4995
Volume :
130
Issue :
3
Database :
MEDLINE
Journal :
The Laryngoscope
Publication Type :
Academic Journal
Accession number :
31077407
Full Text :
https://doi.org/10.1002/lary.28065