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B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study.
- Source :
-
European journal of nutrition [Eur J Nutr] 2020 Apr; Vol. 59 (3), pp. 1253-1262. Date of Electronic Publication: 2019 May 10. - Publication Year :
- 2020
-
Abstract
- Purpose: Higher folate and vitamin-B12 have been linked to lower risk of overweight. However, whether this is a causal effect of these B-vitamins on obesity risk remains unclear and evidence in older individuals is scarce. This study aimed to assess the role of B-vitamin supplementation and levels on body composition in older individuals.<br />Methods: A double-blind, randomized controlled trial in 2919 participants aged ≥ 65 years with elevated homocysteine levels. The intervention comprised a 2-year supplementation with a combination of folic acid (400 µg) and vitamin B12 (500 µg), or with placebo. Serum folate, vitamin-B12, active vitamin-B12 (HoloTC), methylmalonic acid (MMA), and anthropometrics were measured at baseline and after 2 years of follow-up. Dietary intake of folate and vitamin-B12 was measured at baseline in a subsample (n = 603) using a validated food-frequency questionnaire. Fat mass index (FMI) and fat-free mass index (FFMI) were assessed with Dual Energy X-ray absorptiometry (DXA).<br />Results: Cross-sectional analyses showed that a 1 nmol/L higher serum folate was associated with a 0.021 kg/m <superscript>2</superscript> lower BMI (95% CI - 0.039; - 0.004). Higher HoloTC (per pmol/L log-transformed) was associated with a 0.955 kg/m <superscript>2</superscript> higher FMI (95% CI 0.262; 1.647), and higher MMA (per μgmol/L) was associated with a 1.108 kg/m <superscript>2</superscript> lower FMI (95% CI - 1.899; - 0.316). However, random allocation of B-vitamins did not have a significant effect on changes in BMI, FMI or FFMI during 2 years of intervention.<br />Conclusions: Although observational data suggested that folate and vitamin B12 status are associated with body composition, random allocation of a supplement with both B-vitamins combined versus placebo did not confirm an effect on BMI or body composition.
- Subjects :
- Absorptiometry, Photon
Aged
Body Mass Index
Cross-Sectional Studies
Double-Blind Method
Female
Folic Acid administration & dosage
Folic Acid blood
Follow-Up Studies
Humans
Male
Netherlands
Risk
Vitamin B 12 administration & dosage
Vitamin B 12 blood
Vitamin B Complex administration & dosage
Vitamin B Complex blood
Adipose Tissue drug effects
Body Composition drug effects
Dietary Supplements
Folic Acid pharmacology
Vitamin B 12 pharmacology
Vitamin B Complex pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1436-6215
- Volume :
- 59
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 31076856
- Full Text :
- https://doi.org/10.1007/s00394-019-01985-8