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Early nasal microbiota and acute respiratory infections during the first years of life.
- Source :
-
Thorax [Thorax] 2019 Jun; Vol. 74 (6), pp. 592-599. Date of Electronic Publication: 2019 May 10. - Publication Year :
- 2019
-
Abstract
- Background: Emerging evidence shows that airway microbiota may modulate local immune responses, thereby contributing to the susceptibility and severity of acute respiratory infections (ARIs). However, there are little data on the longitudinal relationships between airway microbiota and susceptibility to ARIs in children.<br />Objective: We aimed to investigate the association of early nasal microbiota and the subsequent risk of ARIs during the first years of life.<br />Methods: In this prospective population-based birth-cohort study in Finland, we followed 839 healthy infants for ARIs from birth to age 24 months. Nasal microbiota was tested using 16S rRNA gene sequencing at age 2 months. We applied an unsupervised clustering approach to identify early nasal microbiota profiles, and examined the association of profiles with the rate of ARIs during age 2-24 months.<br />Results: We identified five nasal microbiota profiles dominated by Moraxella , Streptococcus , Dolosigranulum , Staphylococcus and Corynebacteriaceae , respectively. Incidence rate of ARIs was highest in children with an early Moraxella -dominant profile and lowest in those with a Corynebacteriaceae -dominant profile (738 vs 552/100 children years; unadjusted incidence rate ratio (IRR), 1.34; 95% CI 1.16 to 1.54; p < 0.001). After adjusting for nine potential confounders, the Moraxella -dominant profile-ARI association persisted (adjusted IRR (aIRR), 1.19; 95% CI 1.04 to 1.37; p = 0.01). Similarly, the incidence rate of lower respiratory tract infections (a subset of all ARIs) was significantly higher in children with an early Moraxella -dominant profile (aIRR, 2.79; 95% CI 1.04 to 8.09; p = 0.04).<br />Conclusion: Moraxella -dominant nasal microbiota profile in early infancy was associated with an increased rate of ARIs during the first 2 years of life.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Acute Disease
Corynebacterium isolation & purification
Disease Susceptibility
Female
Finland epidemiology
Gram-Positive Bacteria isolation & purification
Humans
Incidence
Infant
Infant, Newborn
Male
Moraxella isolation & purification
Prospective Studies
Respiratory Tract Infections epidemiology
Staphylococcus isolation & purification
Streptococcus isolation & purification
Microbiota
Nasal Cavity microbiology
Respiratory Tract Infections microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-3296
- Volume :
- 74
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Thorax
- Publication Type :
- Academic Journal
- Accession number :
- 31076501
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2018-212629