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Site-Selective, Remote sp 3 C-H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2019 Jul 05; Vol. 25 (38), pp. 9001-9005. Date of Electronic Publication: 2019 Jun 06. - Publication Year :
- 2019
-
Abstract
- A photoinduced carboxylation of alkyl halides with CO <subscript>2</subscript> at remote sp <superscript>3</superscript> C-H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.<br /> (© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 25
- Issue :
- 38
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 31074058
- Full Text :
- https://doi.org/10.1002/chem.201902095