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In vitro activity of ceftaroline in combination with other antimicrobials active against Staphylococcus spp.
- Source :
-
Enfermedades infecciosas y microbiologia clinica (English ed.) [Enferm Infecc Microbiol Clin (Engl Ed)] 2020 Jan; Vol. 38 (1), pp. 25-27. Date of Electronic Publication: 2019 May 06. - Publication Year :
- 2020
-
Abstract
- Introduction: We evaluated the in vitro activity of the combination of ceftaroline with daptomycin, linezolid and vancomycin against methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus (CNS).<br />Material and Methods: We analysed 70 staphylococcal strains (31 S. aureus and 39 CNS) with the Etest using the MIC:MIC ratio method and calculation of fractional inhibitory concentration indexes.<br />Results: The combination of ceftaroline with daptomycin showed an additive effect (53.2%) and synergy (6.6%) against methicillin-susceptible S. aureus, and an additive effect (81.2%) against methicillin-resistant S. aureus (MRSA). This combination also showed an additive effect against 33% of linezolid-susceptible CNS and was not synergistic against linezolid-resistant CNS. The combination of ceftaroline with vancomycin was synergistic (87%) and ceftaroline with linezolid was additive (37%) against MRSA.<br />Conclusions: The combinations of ceftaroline with daptomycin, vancomycin or linezolid showed additive and/or synergistic effects against methicillin-resistant Staphylococcus.<br /> (Copyright © 2019 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 2529-993X
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Enfermedades infecciosas y microbiologia clinica (English ed.)
- Publication Type :
- Academic Journal
- Accession number :
- 31072712
- Full Text :
- https://doi.org/10.1016/j.eimc.2019.03.007