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Methodology for Identification of Cysteine-Reactive Covalent Inhibitors.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 1967, pp. 245-262. - Publication Year :
- 2019
-
Abstract
- Covalent fragments are an emerging technology to discover covalent ligands in target-based or phenotypic screens. Here we describe screening of cysteine-reactive covalent fragments against a protein of interest using mass spectrometry or enzymatic methods.
- Subjects :
- Humans
Ligands
Molecular Structure
Cysteine chemistry
Mass Spectrometry methods
Subjects
Details
- Language :
- English
- ISSN :
- 1940-6029
- Volume :
- 1967
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 31069775
- Full Text :
- https://doi.org/10.1007/978-1-4939-9187-7_15