Prevalence of hepatitis E virus infection in multiple transfused Brazilian patients with thalassemia and sickle cell disease.

Authors :: Slavov SN
Maçonetto JDM
Martinez EZ
Silva-Pinto AC
Covas DT
Eis-Hübinger AM
Kashima S
Source :: Journal of medical virology [J Med Virol] 2019 Sep; Vol. 91 (9), pp. 1693-1697. Date of Electronic Publication: 2019 May 22.
Publication Year :: 2019
Abstract: Hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. The virus is acquired by fecal-oral route; however, it can also be transmitted by blood transfusion. The objective of the study was to examine anti-HEV immunoglobulin G and HEV RNA prevalence in multiple transfused patients with thalassemia and sickle cell disease (SCD), and in blood donors. The HEV seroprevalence in the patients was 13% (20% in thalassemics; 7.7% in SCD), and 11% in blood donors. No positive result for HEV RNA was obtained. This is a pioneer study examining HEV circulation in Brazilian patients with hemoglobinopathies.<br /> (© 2019 Wiley Periodicals, Inc.)

Subjects :: Anemia, Sickle Cell therapy
Blood Transfusion
Brazil epidemiology
Female
Humans
Immunoglobulin G blood
Immunoglobulin G immunology
Male
Prevalence
Public Health Surveillance
RNA, Viral
Seroepidemiologic Studies
Thalassemia therapy
Anemia, Sickle Cell complications
Hepatitis E epidemiology
Hepatitis E etiology
Hepatitis E virus immunology
Thalassemia complications

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