Back to Search Start Over

Diabetic trends and associated mortality in tuberculosis patients in Texas, a large population-based analysis.

Authors :
Nguyen DT
Graviss EA
Source :
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2019 May; Vol. 116S, pp. S59-S65. Date of Electronic Publication: 2019 Apr 26.
Publication Year :
2019

Abstract

Background: Tuberculosis (TB) and diabetes mellitus (DM) comorbidity (TB-DM) is a major public health challenge worldwide. This analysis aimed to determine the risk factors and trends associated with TB-DM morbidity and mortality.<br />Methods: Risk factors for TB-DM morbidity and mortality were identified by logistic regression using de-identified surveillance data of all TB patients from Texas, USA. reported between 01/2010-12/2016. Non-parametric testing was used for the morbidity and mortality trends.<br />Results: From 2010 to 2016, 1400/9002 (15.6%) TB patients were diabetic with an annual prevalence increase from 12.5% to 18.7% (p = 0.005). Reported TB-DM patients had a higher mortality (10.3%) than non-DM patients (7.6%, p = 0.001) with nearly a 3-fold increase in the odds of death (overall and during treatment). Older age, being Hispanic, chronic kidney failure, pulmonary cavitation and positive TB culture or smear were associated with TB-DM. Age ≥45, US-birth, resident of long-term care facility, injecting-drug user, chronic kidney disease, TB meningitis, abnormal chest radiograph, non-conversion of culture, and HIV(+) were independently associated with a higher mortality.<br />Conclusions: TB-DM is an increasing public health problem in Texas with significantly high mortality. Risk factors for mortality determined by multivariate modeling will provide a foundation for the development of more effective strategies for TB-DM management.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1873-281X
Volume :
116S
Database :
MEDLINE
Journal :
Tuberculosis (Edinburgh, Scotland)
Publication Type :
Academic Journal
Accession number :
31064712
Full Text :
https://doi.org/10.1016/j.tube.2019.04.011