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Diabetic trends and associated mortality in tuberculosis patients in Texas, a large population-based analysis.
- Source :
-
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2019 May; Vol. 116S, pp. S59-S65. Date of Electronic Publication: 2019 Apr 26. - Publication Year :
- 2019
-
Abstract
- Background: Tuberculosis (TB) and diabetes mellitus (DM) comorbidity (TB-DM) is a major public health challenge worldwide. This analysis aimed to determine the risk factors and trends associated with TB-DM morbidity and mortality.<br />Methods: Risk factors for TB-DM morbidity and mortality were identified by logistic regression using de-identified surveillance data of all TB patients from Texas, USA. reported between 01/2010-12/2016. Non-parametric testing was used for the morbidity and mortality trends.<br />Results: From 2010 to 2016, 1400/9002 (15.6%) TB patients were diabetic with an annual prevalence increase from 12.5% to 18.7% (p = 0.005). Reported TB-DM patients had a higher mortality (10.3%) than non-DM patients (7.6%, p = 0.001) with nearly a 3-fold increase in the odds of death (overall and during treatment). Older age, being Hispanic, chronic kidney failure, pulmonary cavitation and positive TB culture or smear were associated with TB-DM. Age ≥45, US-birth, resident of long-term care facility, injecting-drug user, chronic kidney disease, TB meningitis, abnormal chest radiograph, non-conversion of culture, and HIV(+) were independently associated with a higher mortality.<br />Conclusions: TB-DM is an increasing public health problem in Texas with significantly high mortality. Risk factors for mortality determined by multivariate modeling will provide a foundation for the development of more effective strategies for TB-DM management.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Comorbidity
Databases, Factual
Diabetes Mellitus diagnosis
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Population Surveillance
Prevalence
Prognosis
Risk Assessment
Risk Factors
Texas epidemiology
Time Factors
Tuberculosis diagnosis
Young Adult
Diabetes Mellitus mortality
Tuberculosis mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1873-281X
- Volume :
- 116S
- Database :
- MEDLINE
- Journal :
- Tuberculosis (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 31064712
- Full Text :
- https://doi.org/10.1016/j.tube.2019.04.011