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Clinical significance of traditional clinical parameters and inflammatory biomarkers for the prognosis of patients with spinal chondrosarcoma: a retrospective study of 150 patients in a single center.
- Source :
-
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2019 Jun; Vol. 28 (6), pp. 1468-1479. Date of Electronic Publication: 2019 May 04. - Publication Year :
- 2019
-
Abstract
- Background: To investigate the clinical significance of five inflammatory biomarkers and conventional clinical parameters in prognostic prediction of spinal chondrosarcoma.<br />Methods: Univariate and multivariate analyses were performed to investigate independent prognostic factors for recurrence and death of patients with spinal chondrosarcoma. Disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan-Meier curve, and differences were analyzed by log-rank test. The optimal cutoff values for NLR, PLR, LMR, and CAR were determined by X-tile program.<br />Results: The optimal cutoff value for NLR, PLR, LMR, AGR, and CAR was 2.7, 200, 3.0, 1.5, and 0.2, respectively. Of the 150 patients included, recurrence was detected in 105 patients, and death occurred in 78 patients. Multivariate analysis indicated that Tomita I-III, total resection, and CAR < 0.2 were significantly associated with longer DFS. Meanwhile, preoperative Frankel score D-E, total resection, and CAR < 0.2 were favorable prognostic factors for OS. Subtype analysis showed that only total resection was an independent prognostic factor for DFS of recurrent spinal chondrosarcoma.<br />Conclusion: Total resection could significantly reduce the recurrence rate of spinal chondrosarcoma and improve OS of chondrosarcoma patients. Tomita classification I-III was a favorable factor for DFS, and preoperative Frankel score A-C was an adverse prognostic factor for OS. CAR was the most robust prognostic indicator with a discriminatory ability as compared with other inflammatory indicators. These slides can be retrieved under Electronic Supplementary Material.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers blood
C-Reactive Protein analysis
Cell Count
Child
China epidemiology
Chondrosarcoma blood
Disease-Free Survival
Female
Follow-Up Studies
Humans
Lymphocyte Count
Male
Middle Aged
Monocytes metabolism
Neoplasm Recurrence, Local
Neutrophils metabolism
Platelet Count
Prognosis
Retrospective Studies
Serum Albumin
Serum Globulins
Spinal Neoplasms blood
Young Adult
Chondrosarcoma mortality
Chondrosarcoma surgery
Spinal Neoplasms mortality
Spinal Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0932
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 31055664
- Full Text :
- https://doi.org/10.1007/s00586-019-05993-4