Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd 0 -CalB CLEA as a Biohybrid Catalyst.

Authors :: Gustafson KPJ
Görbe T
de Gonzalo-Calvo G
Yuan N
Schreiber CL
Shchukarev A
Tai CW
Persson I
Zou X
Bäckvall JE
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2019 Jul 11; Vol. 25 (39), pp. 9174-9179. Date of Electronic Publication: 2019 Jun 24.
Publication Year :: 2019
Abstract: Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.<br /> (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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