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Assessment of Serious Acute and Chronic Idiosyncratic Drug-Induced Liver Injury in Clinical Practice.
- Source :
-
Seminars in liver disease [Semin Liver Dis] 2019 Jul; Vol. 39 (3), pp. 381-394. Date of Electronic Publication: 2019 May 02. - Publication Year :
- 2019
-
Abstract
- Drug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF) in developed countries. The extremely variable phenotype of DILI, both in presentation and in severity, is one of the distinctive characteristics of the disease and one of the major challenges that hepatologists face when assessing hepatotoxicity cases. A new Hy's law that more accurately predicts the risk of ALF related to DILI has been proposed and validated. Other prognostic scoring algorithms for the early identification of DILI patients who may go on to develop ALF have been developed as it is of most clinical relevance to stratify patients for closer monitoring. Recent data indicate that acute DILI often presents a more prolonged resolution or evolves into chronicity at a higher frequency than other forms of acute liver injury. Risk factors for chronicity, specific phenotypes, and histological features are discussed in this study. Biomarkers to predict DILI outcome are in need.<br />Competing Interests: None.<br /> (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Subjects :
- Biomarkers blood
Blood Coagulation Disorders etiology
Chemical and Drug Induced Liver Injury blood
Chemical and Drug Induced Liver Injury, Chronic blood
Chemical and Drug Induced Liver Injury, Chronic complications
Chemical and Drug Induced Liver Injury, Chronic etiology
Chemical and Drug Induced Liver Injury, Chronic pathology
Drug Eruptions etiology
Fatty Liver etiology
Hepatic Encephalopathy etiology
Humans
Phenotype
Risk Factors
Severity of Illness Index
Chemical and Drug Induced Liver Injury complications
Chemical and Drug Induced Liver Injury pathology
Liver Failure, Acute etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-8971
- Volume :
- 39
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Seminars in liver disease
- Publication Type :
- Academic Journal
- Accession number :
- 31049898
- Full Text :
- https://doi.org/10.1055/s-0039-1685519