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The EC-HDA9 complex rhythmically regulates histone acetylation at the TOC1 promoter in Arabidopsis .
- Source :
-
Communications biology [Commun Biol] 2019 Apr 23; Vol. 2, pp. 143. Date of Electronic Publication: 2019 Apr 23 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Circadian clocks are conserved time-keeper mechanisms in some prokaryotes and higher eukaryotes. Chromatin modification is emerging as key regulatory mechanism for refining core clock gene expression. Rhythmic changes in histone marks are closely associated to the TIMING OF CAB EXPRESSION 1 ( TOC1 ) Arabidopsis clock gene. However, the chromatin-related modifiers responsible for these marks remain largely unknown. Here, we uncover that the chromatin modifier HISTONE DEACETYLASE 9 (HDA9) and the Evening complex (EC) component EARLY FLOWERING 3 (ELF3) directly interact to regulate the declining phase of TOC1 after its peak expression. We found that HDA9 specifically binds to the TOC1 promoter through the interaction with ELF3. The EC-HDA9 complex promotes H3 deacetylation at the TOC1 locus, contributing to suppressing TOC1 expression during the night, the time of EC function. Therefore, we have identified the mechanism by which the circadian clock intertwines with chromatin-related components to shape the circadian waveforms of gene expression in Arabidopsis .<br />Competing Interests: The authors declare no competing interests.
- Subjects :
- Acetylation
Arabidopsis genetics
Arabidopsis metabolism
Arabidopsis Proteins genetics
Arabidopsis Proteins physiology
Genes, Plant
Histone Deacetylases genetics
Multiprotein Complexes
Promoter Regions, Genetic
Protein Interaction Mapping
Protoplasts
Seedlings growth & development
Transcription Factors genetics
Arabidopsis physiology
Arabidopsis Proteins metabolism
Circadian Rhythm genetics
Gene Expression Regulation, Developmental physiology
Gene Expression Regulation, Plant physiology
Histone Deacetylases physiology
Histones metabolism
Protein Processing, Post-Translational
Transcription Factors physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2399-3642
- Volume :
- 2
- Database :
- MEDLINE
- Journal :
- Communications biology
- Publication Type :
- Academic Journal
- Accession number :
- 31044168
- Full Text :
- https://doi.org/10.1038/s42003-019-0377-7