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Proton pump inhibitors versus Cryptococcus species: effects on in vitro susceptibility and melanin production.
- Source :
-
Future microbiology [Future Microbiol] 2019 Apr; Vol. 14, pp. 489-497. Date of Electronic Publication: 2019 Apr 29. - Publication Year :
- 2019
-
Abstract
- Aim: This study aimed to evaluate the effects of proton pump inhibitors (PPIs) on growth and melanin production by Cryptococcus spp. Materials & methods: Minimum inhibitory concentrations (MICs) of omeprazole, esomeprazole, rabeprazole, pantoprazole and lansoprazole against Cryptococcus spp. were determined and the effect of PPIs on melanin production was evaluated, in the presence or absence of copper sulfate or glutathione. Results: PPIs showed MICs ranging from 125-1000 μg/ml and decreased melanization by Cryptococcus cells. Addition of copper sulfate or gluthatione restored melanogenesis of cells grown in the presence of PPIs. The presence of PPIs and glyphosate decreased copper sulfate toxicity (1 mM). Conclusion: PPIs inhibited melanogenesis of Cryptococcus spp., possibly by chelating copper or inhibiting copper ATPase transport.
- Subjects :
- Adenosine Triphosphatases
Copper
Copper Sulfate metabolism
Cryptococcus growth & development
Culture Media chemistry
Esomeprazole pharmacology
Glutathione metabolism
Glycine analogs & derivatives
Humans
Lansoprazole pharmacology
Microbial Sensitivity Tests
Omeprazole pharmacology
Pantoprazole pharmacology
Rabeprazole pharmacology
Glyphosate
Antifungal Agents pharmacology
Cryptococcus drug effects
Cryptococcus metabolism
Melanins biosynthesis
Proton Pump Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1746-0921
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Future microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 31033338
- Full Text :
- https://doi.org/10.2217/fmb-2018-0340