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Inherited Platelet Disorders: A Modern Approach to Evaluation and Treatment.
- Source :
-
Hematology/oncology clinics of North America [Hematol Oncol Clin North Am] 2019 Jun; Vol. 33 (3), pp. 471-487. Date of Electronic Publication: 2019 Apr 02. - Publication Year :
- 2019
-
Abstract
- The inherited platelet disorders are a heterogeneous group of disorders that can be pleotropic in their clinical presentations. They may present with variable platelet counts and bleeding, making their diagnosis difficult. New diagnostic tools range from flow cytometric platelet function assessments to next-generation sequencing. Several platelet disorders may now be treated with gene therapy or bone marrow transplant. Improved understanding of the molecular and biologic mechanisms of the inherited platelet disorders may lead to novel targeted therapies.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Biological Products therapeutic use
Blood Platelet Disorders diagnosis
Blood Platelet Disorders genetics
Bone Marrow Transplantation methods
Hemorrhage diagnosis
Hemorrhage genetics
Humans
Blood Platelet Disorders therapy
Blood Platelets metabolism
Genetic Therapy methods
Hemorrhage therapy
High-Throughput Nucleotide Sequencing methods
Platelet Count
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1977
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Hematology/oncology clinics of North America
- Publication Type :
- Academic Journal
- Accession number :
- 31030814
- Full Text :
- https://doi.org/10.1016/j.hoc.2019.01.008