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Diffuse pruritic erythema as a clinical manifestation in anti-SAE antibody-associated dermatomyositis: a case report and literature review.
- Source :
-
Clinical rheumatology [Clin Rheumatol] 2019 Aug; Vol. 38 (8), pp. 2189-2193. Date of Electronic Publication: 2019 Apr 27. - Publication Year :
- 2019
-
Abstract
- Anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibodies have been recently discovered especially for myosin and identified as dermatomyositis (DM) marker. The frequency of anti-SAE antibodies in DM patients is extremely low. Diffuse pruritic erythema may be one kind of clinical manifestations of DM with anti-SAE antibodies. In this report, a 48-year-old female patient with amyopathic dermatomyositis (ADM) carrying anti-SAE antibodies presented diffuse pruritic erythema for 5 months. Diffuse pruritic erythema improved after treatment with prednisolone, cyclosporine, and thalidomide. The clinical characteristics of 75 previously reported cases with anti-SAE antibody-positive DM were reviewed, and the manifestations of the Asian and Western cohorts were compared. It was revealed that the Asian patients were more susceptible to diffuse erythema (17/34 vs. 3/41, P = 0.000), dysphagia (16/34 vs. 10/41, P = 0.040), and interstitial lung disease (ILD) (21/34 vs. 5/41, P = 0.000) compared with the Western patients. The frequency of malignancy in the Asian cohort was significantly higher than that in the Western cohort (10/34 vs. 4/41, P = 0.030).
- Subjects :
- Antibodies immunology
Asian People
Cyclosporine administration & dosage
Dermatomyositis ethnology
Erythema ethnology
Female
Humans
Methotrexate administration & dosage
Middle Aged
Prednisolone administration & dosage
Pruritus ethnology
Thalidomide administration & dosage
Treatment Outcome
Dermatomyositis complications
Erythema complications
Pruritus complications
Ubiquitin-Activating Enzymes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1434-9949
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 31030362
- Full Text :
- https://doi.org/10.1007/s10067-019-04562-w