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Corynebacterium coyleae as potential urinary tract pathogen.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2019 Jul; Vol. 38 (7), pp. 1339-1342. Date of Electronic Publication: 2019 Apr 27. - Publication Year :
- 2019
-
Abstract
- Corynebacterium coyleae is part of the commensal microflora of the skin, urethra, mucous membranes, and genital tract. Isolates from patients with urinary tract infection (UTI) were reported, but the pathogenic potential of this species has not been defined yet. The aim of the study is to determine whether C. coyleae could be the etiological agent of UTI and to analyze its antibiotic susceptibility. Urine samples were cultured quantitatively according to accepted laboratory procedures. The identification of bacterial isolates was carried out using the Vitek MS (bioMérieux) and antibiotic susceptibility was tested using disc diffusion according to EUCAST guidelines. Between 1 January 2017 and 30 October 2018, a total of 39 C. coyleae strains were isolated. This represented 0.32% of all urine samples cultured in the laboratory during the collection period. The strains were isolated from samples obtained from 35 women and 3 men (age median for all-64 years). One female patient presented with C. coyleae in her urine twice at an interval of 21 months. In six cases of UTI, C. coyleae was isolated in monoculture. The isolates had the same resistance pattern. A total of 11 strains were obtained from cases with a clinical diagnosis of UTI. In 13 cases, the strain was cultured in a monoculture and in 28 cases with accompanying species. All strains were susceptible to vancomycin. However, resistance to ciprofloxacin was observed for 58.4% of the strains. Urine isolates of C. coyleae must be considered as contamination or normal flora in most cases (28/39, 72%). In the remaining cases, it can be considered as potential etiologic agents, mostly in women and especially in the 6 UTI cases where C. coyleae was found as the single culture-positive species. Several of these isolates demonstrate resistance to antibiotics commonly used in empiric treatment of urinary tract infections.
- Subjects :
- Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents therapeutic use
Ciprofloxacin therapeutic use
Corynebacterium drug effects
Corynebacterium isolation & purification
Corynebacterium Infections drug therapy
Drug Resistance, Multiple, Bacterial
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Retrospective Studies
Urinary Tract Infections drug therapy
Young Adult
Corynebacterium pathogenicity
Corynebacterium Infections urine
Urinary Tract microbiology
Urinary Tract Infections microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 38
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 31030337
- Full Text :
- https://doi.org/10.1007/s10096-019-03565-4