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Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2019 Jun; Vol. 143 (2), pp. 251-260. Date of Electronic Publication: 2019 Apr 25. - Publication Year :
- 2019
-
Abstract
- Purpose: Germ cell tumors (GCT) in the central nervous system (CNS) are rare tumors that occur with highest frequency in males, Asian populations, and children less than age 20 years. Due to the rarity of these tumors, their patterns of incidence are not well-described. The aim of this study is to provide the most up-to-date data on incidence and survival patterns for CNS GCT by sex, race, and age at diagnosis.<br />Methods: The Central Brain Tumor Registry of the United States (CBTRUS) is the largest aggregation of population-based incidence data on primary brain and other CNS tumors in the United States, containing incidence data from 51 central cancer registries and representing 100% of the US population. The current study used the CBTRUS analytic file to examine incidence (IR) of CNS GCT from 2006 to 2015, as well as registry data from the Surveillance, Epidemiology, and End Results (SEER) program to examine survival.<br />Results: Males had greater IR than females in all CNS GCT histologies examined. Asian and Pacific Islanders had a significantly greater IR of CNS GCT than the other race categories. We confirmed that CNS GCT IR was greatest for those age 10-14 years and male. Overall survival rates were high for malignant CNS GCT, germinoma, mixed GCT, and malignant teratoma.<br />Conclusions: There is significant variation in CNS GCT incidence by sex, race, and age at diagnosis. Ascertaining accurate incidence and survival rates of CNS GCT provides vital information usable in real time for clinicians, public health planners, patients, and their families.
- Subjects :
- Adolescent
Adult
Age Factors
Central Nervous System Neoplasms pathology
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Neoplasms, Germ Cell and Embryonal pathology
Prognosis
Survival Rate
Time Factors
United States epidemiology
Young Adult
Central Nervous System Neoplasms epidemiology
Central Nervous System Neoplasms mortality
Neoplasms, Germ Cell and Embryonal epidemiology
Neoplasms, Germ Cell and Embryonal mortality
Registries statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7373
- Volume :
- 143
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31025275
- Full Text :
- https://doi.org/10.1007/s11060-019-03173-4