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Treatment and outcome of Unicentric Castleman Disease: a retrospective analysis of 71 cases.
- Source :
-
British journal of haematology [Br J Haematol] 2019 Jul; Vol. 186 (2), pp. 269-273. Date of Electronic Publication: 2019 Apr 23. - Publication Year :
- 2019
-
Abstract
- We retrospectively analysed 71 cases of Unicentric Castleman disease, a rare, usually asymptomatic, benign lymphoproliferative disorder presenting as a unique nodal mass. Although surgery is considered as the gold standard therapy, only 38 patients (54%) underwent initial surgical resection and 95% were cured. An additional 9 patients had surgery after an attempt at medical reduction. Reduction therapy was used in 21 patients with a 55% response rate, but without evidence for an optimal regimen. Radiotherapy was limited to 8 patients because of associated toxicity. Watch and wait was considered in 13 asymptomatic patients and 11 of these remained stable for up to 17 years.<br /> (© 2019 British Society for Haematology and John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 186
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 31016730
- Full Text :
- https://doi.org/10.1111/bjh.15921