Back to Search
Start Over
Mancozeb impaired male fertility in rabbits with trials of glutathione detoxification.
- Source :
-
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Jul; Vol. 105, pp. 86-98. Date of Electronic Publication: 2019 Apr 20. - Publication Year :
- 2019
-
Abstract
- The study aims to evaluate the potential reproductive toxicity induced by mancozeb fungicide in male rabbits and to examine the ameliorative effect of glutathione (GSH), a non-enzymatic antioxidant, against mancozeb reproductive toxicity. Mancozeb is a member of the dithiocarbamates group currently in use in the management of fungal diseases of plants. To achieve these aims, mature male White New-Zealand rabbits of 4-5 months old were randomly assigned to four groups of 9 animals each: control, mancozeb only, mancozeb and GSH, and GSH only. This study discovered a significant reduction in serum FSH, LH, testosterone and testicular LDH, ACP, and ALP levels in the groups of mancozeb-treated rabbits compared with control. The mancozeb-treated groups also showed significant losses in sperm viability, along with a significant increase in the number of abnormal sperms. Finally, an upregulation in steroidogenic 3β-HSD enzyme activity was noted in mancozeb-treated rabbits. Histopathological inspection of the testicles established disruption of the germinal epithelium with vacuolization of Leydig cells and reduced spermatogenic cells. GSH co-administration increased serum concentrations of FSH, LH, testosterone, and levels of the testicular enzymes: LDH, ACP, and ALP. Improved steroidogenesis was indicated in this group by a significant improvement in the testicular 3β-HSD enzyme, by a significant increase in sperm viability, and by a significant decrease in the number of abnormal sperms. The findings of this study suggest that mancozeb exposure has anti-spermatogenic and anti-steroidogenic adverse effects in rabbits and administration of GSH may alleviate the reproductive toxicity.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Fertility drug effects
Follicle Stimulating Hormone blood
Luteinizing Hormone blood
Male
Rabbits
Random Allocation
Reproduction drug effects
Spermatogenesis drug effects
Spermatozoa abnormalities
Spermatozoa drug effects
Testis drug effects
Testis pathology
Testosterone blood
Antioxidants pharmacology
Fungicides, Industrial toxicity
Glutathione pharmacology
Maneb toxicity
Zineb toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0295
- Volume :
- 105
- Database :
- MEDLINE
- Journal :
- Regulatory toxicology and pharmacology : RTP
- Publication Type :
- Academic Journal
- Accession number :
- 31014950
- Full Text :
- https://doi.org/10.1016/j.yrtph.2019.04.012