Validation and Application of an HPLC-DAD Method for Routine Therapeutic Drug Monitoring of Ceftobiprole.

Authors :: Lima B
Bodeau S
Quinton MC
Leven C
Lemaire-Hurtel AS
Bennis Y
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Jun 24; Vol. 63 (7). Date of Electronic Publication: 2019 Jun 24 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Ceftobiprole is a fifth-generation cephalosporin approved for the treatment of pneumonia, with a broad antibacterial spectrum, including potent activity against methicillin-resistant Staphylococcus aureus As for the other cephalosporins, high pharmacokinetic variability and concentration-dependent neurotoxicity are expected. We describe here the first simple and rapid analytical method intended for ceftobiprole serum concentration monitoring. We report the data of 5 patients treated with ceftobiprole, among who 2 developed reversible neurological disorders with high ceftobiprole serum concentration.<br /> (Copyright © 2019 American Society for Microbiology.)

Subjects :: Aged
Anti-Bacterial Agents adverse effects
Calibration
Cephalosporins adverse effects
Female
Humans
Male
Seizures chemically induced
Anti-Bacterial Agents blood
Cephalosporins blood
Chromatography, High Pressure Liquid methods
Drug Monitoring methods

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