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Mechanisms behind the atherothrombotic effects of acrolein, a review.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Jul; Vol. 129, pp. 38-53. Date of Electronic Publication: 2019 Apr 19. - Publication Year :
- 2019
-
Abstract
- Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The majority of cardiovascular complications are secondary to atherosclerosis. Extensive evidence has showed that environmental pollutants such as cigarette smoke and automobile exhaust increase the risk of developing atherosclerosis. Acrolein, a highly reactive unsaturated aldehyde, is found as a contaminant in air, food and water. Investigations during the last decades have shown that acrolein via various mechanisms such as oxidative stress, enhancement of inflammatory processes and the activation of matrix metalloproteases can initiate and accelerate atherosclerotic lesions formation. Furthermore, exposure to acrolein has been suggested to induce or exacerbate systemic dyslipidemia, an important risk factor for the development of atherosclerosis. Finally, there are reports which indicate acrolein can increase platelet activation and stimulation of the coagulation cascade which subsequently leads to thrombosis. Even a modest reduction of pollutants such as acrolein can have substantial effects on population health. Public health efforts to reduce acrolein exposures from known sources may lower the prevalence of vascular disease. This review focuses on the potential pathways and mechanisms behind the acrolein-induced atherothrombotic effects.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Acrolein pharmacokinetics
Dyslipidemias chemically induced
Environmental Exposure
Enzyme Activation
Extracellular Matrix metabolism
Humans
Inflammation chemically induced
Matrix Metalloproteinases metabolism
Plaque, Atherosclerotic pathology
Toxicokinetics
Acrolein toxicity
Atherosclerosis chemically induced
Thrombosis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 129
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 31009736
- Full Text :
- https://doi.org/10.1016/j.fct.2019.04.034